Terpenoid metabolism
Terpenoids are produced from the 5-carbon isoprene units, isopentenyl diphosphate and dimethylallyl diphosphate. The pathway which produces the 5-carbon isoprene units is absent is Cryptosporidium species and need to be acquired from host. Terpenoids are used as precursors for production of sterols and steroids in animals. Some proteins have terpenoid moieties attached to them in order to enhance their attachment to membranes. This pathway produces polyprenyl pyrophosphate, undecaprenyl pyrophosphate and prenylated proteins such as S-geranylgeranyl protein as the end products of the pathway. This pathway is identical to the pathways of Plasmodium falciparum and Toxoplasma gondii.
Enzyme | EC Number | Gene id |
---|---|---|
Methyltransferase, MiaB | 2.1.1.- | TP04_0588 |
Farnesylpyrophosphate synthase (Dimethylallyl-PP transferase/Geranyl transferase) | 2.5.1.1; 2.5.1.10 | TP03_0857 |
Protein farnesyltransferase | 2.5.1.29; 2.5.1.58 | TP02_0810 |
trans-pentaprenyltranstransferase/trans-hexaprenyltranstransferase/trans-octaprenyltranstransferase | 2.5.1.30; 2.5.1.82; 2.5.1.84 | TP03_0238 |
di-trans,poly-cis-decaprenylcistransferase | 2.5.1.31 | TP03_0421 |
Protein geranylgeranyltransferase type I | 2.5.1.59 | TP03_0500 |
Protein geranylgeranyltransferase type II | 2.5.1.60 | TP04_0873 |
tRNA isopentenyltransferase | 2.5.1.75 | TP01_0445 |
Inorganic diphosphatase | 3.6.1.1 | TP02_0061 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
S-adenosylmethionine | Methionine metabolism | S-adenosylhomocysteine | Methionine metabolism |
Dimethylallyl-PP | Isoprenoids metabolism | ||
Isopentenyl-PP | Isoprenoids metabolism |
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