Mannose and fructose metabolism

The mannose and fructose metabolism pathway presented here is shorter than the pathway for Toxoplasma gondii. This pathway utilises fructose, a hexose (may be from host) and fructose-6-phosphate, a glycolysis intermediate for the production of important nucleotide sugar GDP-D-mannose in Theileria species. This is an essential substrate for glycosylphosphatidylinositol (GPI) anchor biosynthesis and dolichol metabolism. GDP-L-fucose is also synthesised in T. gondii and Plasmodium falciparum, which is missing in Cryptosporidium and Theileria species.


Enzyme EC Number Gene id
Hexokinase TA19800
Hexokinase TA19810
Mannose-1-phosphate guanylyltransferase TA14300
Mannose-6-phosphate isomerase TA11125
Phosphomannomutase TA07020


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Sources and fates of metabolites


Substrate Source pathways Product Fate pathways
beta-D-Fructose-6P Glycolysis GDP-D-Mannose Dolichol metabolism
beta-D-Fructose Host    
D-Mannose Host