Nitrogen metabolism
The nitrogen metabolism pathway is a metabolic capability that is same in Toxoplasma gondii and Plasmodium falciparum. This shows the utilisation of nitrate and nitrite from host as source of nitrogen and the de novo synthesis of non essential amino acids glutamate and glutamine from it. The nitrate and nitrite transporters present in the genome are also given in the table below.
Protein | EC Number | Gene id | Protein localisation | Localisation data source |
---|---|---|---|---|
Glutamate dehydrogenase | 1.4.1.2 | TGME49_249390 | Mitochondrion | Previous publication |
Glutamate dehydrogenase | 1.4.1.4 | TGME49_293180 | Cytosol | Previous publication |
Nitrate reductase | 1.7.1.3 | TGME49_262910 | Cytosol | Previous publication |
Nitrite reductase | 1.7.1.4 | TGME49_207620 | Plasma membrane | Previous publication |
Glutamate-ammonia ligase | 6.3.1.2 | TGME49_273490 | Cytosol | Previous publication |
Carbamoyl-phosphate synthase | 6.3.4.16 | TGME49_215260 | Cytosol | Previous publication |
Nitrite transporter | none | TGME49_209800 | Plasma membrane | Previous publication; GO annotation |
Nitrite transporter | none | TGME49_229170 | Membrane | GO annotation |
Nitrite transporter | none | TGME49_292110 | Membrane | GO annotation |
Nitrate transporter | none | TGME49_305770 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Nitrate | Host | Carbamoylphosphate | Pyrimidine metabolism |
Nitrite | Host | L-Glutamine | Glutamate metabolism |
2-oxoglutarate | Pyruvate metabolism, Tricarboxylic acid (TCA) cycle | L-Glutamate | Glutamate metabolism |
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