Nitrogen metabolism
Nitrogen metabolism pathway is a metabolic capability which is same in the Coccidians Neospora caninum and Toxoplasma gondii and in Plasmodium falciparum. This shows the utilisation of nitrate and nitrite from host as source of nitrogen and the de novo synthesis of non essential amino acids glutamate and glutamine from it. The nitrate and nitrite transporters present in the genome are also listed in the table below.
Enzyme | EC Number | Gene id |
---|---|---|
Glutamate dehydrogenase | 1.4.1.2 | NCLIV_065590 |
Glutamate dehydrogenase | 1.4.1.4 | NCLIV_000130 |
Nitrate reductase | 1.7.1.3 | NCLIV_025010 |
Nitrite reductase | 1.7.1.4 | NCLIV_002590 |
Glutamate-ammonia ligase | 6.3.1.2 | NCLIV_034160 |
Carbamoyl-phosphate synthase | 6.3.4.16 | NCLIV_052220 |
Nitrite transporter | none | NCLIV_004050 |
Nitrite transporter | none | NCLIV_012840 |
Nitrite transporter | none | NCLIV_030110 |
Nitrate transporter | none | NCLIV_070110 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Nitrate | Host | Carbamoylphosphate | Pyrimidine metabolism |
Nitrite | Host | L-Glutamine | Glutamate metabolism |
2-oxoglutarate | Pyruvate metabolism, Tricarboxylic acid (TCA) cycle | L-Glutamate | Glutamate metabolism |
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