Mannose and fructose metabolism
The mannose and fructose metabolism pathway presented here is same as the pathway for Toxoplasma gondii (http://www.llamp.net/?q=Mannose%20and%20fructose%20metabolism). The genes for all the enzymes in this pathway are identified in Neospora caninum genome. This pathway utilises fructose, a hexose (may be from host) and fructose-6-phosphate, a glycolysis intermediate for the production of important nucleotide sugars such as GDP-D-mannose and GDP-L-fucose. These compounds are essential substrates for glycosylphosphatidylinositol (GPI) anchor biosynthesis and synthesis of the anchors for N-glycans (N-glycans biosynthesis).
Enzyme | EC Number | Gene id |
---|---|---|
GDP-L-fucose synthase | 1.1.1.271 | NCLIV_014250 |
Hexokinase | 2.7.1.1 | NCLIV_039820 |
Mannose-1-phosphate guanylyltransferase | 2.7.7.13 | NCLIV_028400 |
GDP-mannose 4,6-dehydratase | 4.2.1.47 | NCLIV_015780 |
Mannose-6-phosphate isomerase | 5.3.1.8 | NCLIV_026860 |
Phosphomannomutase | 5.4.2.8 | NCLIV_016330 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
beta-D-Fructose-6P | Glycolysis | GDP-D-Mannose | N-glycan biosynthesis |
beta-D-Fructose | Starch and galactose metabolism, Host | GDP-L-Fucose | N-glycan biosynthesis |
D-Mannose | Host |
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