Mannose and fructose metabolism

The mannose and fructose metabolism pathway presented here is same as the pathway for Toxoplasma gondii ( The genes for all the enzymes in this pathway are identified in Neospora caninum genome. This pathway utilises fructose, a hexose (may be from host) and fructose-6-phosphate, a glycolysis intermediate for the production of important nucleotide sugars such as GDP-D-mannose and GDP-L-fucose. These compounds are essential substrates for glycosylphosphatidylinositol (GPI) anchor biosynthesis and synthesis of the anchors for N-glycans (N-glycans biosynthesis).


Enzyme EC Number Gene id
GDP-L-fucose synthase NCLIV_014250
Hexokinase NCLIV_039820
Mannose-1-phosphate guanylyltransferase NCLIV_028400
GDP-mannose 4,6-dehydratase NCLIV_015780
Mannose-6-phosphate isomerase NCLIV_026860
Phosphomannomutase NCLIV_016330


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Sources and fates of metabolites


Substrate Source pathways Product Fate pathways
beta-D-Fructose-6P Glycolysis GDP-D-Mannose N-glycan biosynthesis
beta-D-Fructose Starch and galactose metabolism, Host GDP-L-Fucose N-glycan biosynthesis
D-Mannose Host