Mannose and fructose metabolism
The mannose and fructose metabolism pathway presented here is same as the MPMP pathway of same name (http://sites.huji.ac.il/malaria/maps/mannosemetpath.html). The genes for all the enzymes in this pathway are identified in Toxoplasma gondii genome. This pathway utilises fructose, a hexose (may be from host) and fructose-6-phosphate, a glycolysis intermediate for the production of important nucleotide sugars such as GDP-D-mannose and GDP-L-fucose. These compounds are essential substrates for glycosylphosphatidylinositol (GPI) anchor biosynthesis and synthesis of the anchors for N-glycans (N-glycans biosynthesis).
Enzyme | EC Number | Gene id | Protein localisation | Localisation data source |
---|---|---|---|---|
GDP-L-fucose synthase | 1.1.1.271 | TGME49_286220 | Nucleus | Previous publication |
Hexokinase | 2.7.1.1 | TGME49_265450 | Cytosol | Apiloc; Previous publication |
Mannose-1-phosphate guanylyltransferase | 2.7.7.13 | TGME49_257960 | Mitochondrion | Previous publication |
GDP-mannose 4,6-dehydratase | 4.2.1.47 | TGME49_238940 | Nucleus | Previous publication |
Mannose-6-phosphate isomerase | 5.3.1.8 | TGME49_260140 | ||
Phosphomannomutase | 5.4.2.8 | TGME49_239710 | Cytosol; Cytoskeleton | GO annotation; Previous publication |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
beta-D-Fructose-6P | Glycolysis | GDP-D-Mannose | N-glycan biosynthesis |
beta-D-Fructose | Starch and galactose metabolism, Host | GDP-L-Fucose | N-glycan biosynthesis |
D-Mannose | Host |
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