Lysine degradation

Toxoplasma gondii and Neospora caninum have saccharopine dehydrogenase to catalyse the degradation of lysine. This pathway also includes a large number of genes coding histone-lysine N-methyltransferase which catalyses protein methylation and acylaminoacyl-peptidase, which hydrolyses trimethyl-lysine from protein.

 

Enzyme EC Number Gene id Protein localisation Localisation data source
Saccharopine dehydrogenase 1.5.1.7 TGME49_215290    
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_211730 Nucleus GO annotation
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_216080    
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_226810 Nucleus GO annotation
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_255970 Nucleus GO annotation
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_257770 Nucleus GO annotation
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_262750 Nucleus Previous publication
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_288330    
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_292170    
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_294610 Nucleus Previous publication
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_295610 Nucleus GO annotation
Histone-lysine N-methyltransferase 2.1.1.43 TGME49_311660 Nucleus GO annotation
Acylaminoacyl-peptidase 3.4.19.1 TGME49_246800    
Lysine-tRNA ligase 6.1.1.6 TGME49_205710 Cytosol Previous publication
Lysine-tRNA ligase 6.1.1.6 TGME49_220350 Apicoplast Previous publication

 

List of genes annotated as tRNA-Lys in Toxoplasma gondii genome

 

TGME49_012230 TGME49_016550 TGME49_039030 TGME49_039040
TGME49_045690 TGME49_045700 TGME49_069228 TGME49_069232
TGME49_100632 TGME49_116590    

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Lysine Lysine biosynthesis Saccharopine Host?