Lysine degradation
Toxoplasma gondii and Neospora caninum have saccharopine dehydrogenase to catalyse the degradation of lysine. This pathway also includes a large number of genes coding histone-lysine N-methyltransferase which catalyses protein methylation and acylaminoacyl-peptidase, which hydrolyses trimethyl-lysine from protein.
Enzyme | EC Number | Gene id | Protein localisation | Localisation data source |
---|---|---|---|---|
Saccharopine dehydrogenase | 1.5.1.7 | TGME49_215290 | ||
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_211730 | Nucleus | GO annotation |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_216080 | ||
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_226810 | Nucleus | GO annotation |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_255970 | Nucleus | GO annotation |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_257770 | Nucleus | GO annotation |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_262750 | Nucleus | Previous publication |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_288330 | ||
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_292170 | ||
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_294610 | Nucleus | Previous publication |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_295610 | Nucleus | GO annotation |
Histone-lysine N-methyltransferase | 2.1.1.43 | TGME49_311660 | Nucleus | GO annotation |
Acylaminoacyl-peptidase | 3.4.19.1 | TGME49_246800 | ||
Lysine-tRNA ligase | 6.1.1.6 | TGME49_205710 | Cytosol | Previous publication |
Lysine-tRNA ligase | 6.1.1.6 | TGME49_220350 | Apicoplast | Previous publication |
List of genes annotated as tRNA-Lys in Toxoplasma gondii genome
TGME49_012230 | TGME49_016550 | TGME49_039030 | TGME49_039040 |
TGME49_045690 | TGME49_045700 | TGME49_069228 | TGME49_069232 |
TGME49_100632 | TGME49_116590 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Lysine | Lysine biosynthesis | Saccharopine | Host? |
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