Vacuolar-ATPase
Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Cryptosporidium genomes.
Enzyme | EC Number | Gene id |
---|---|---|
Vacuolar ATP synthase 16kDa proteolipid subunit | 3.6.3.14 | cgd1_520 |
Vacuolar ATP synthase 16kDa proteolipid subunit | 3.6.3.14 | cgd1_540 |
Vacuolar ATP synthase subunit G1 | 3.6.3.14 | cgd2_250 |
Vacuolar ATP synthase 54kDa proteolipid subunit | 3.6.3.14 | cgd2_3960 |
Vacuolar ATP synthase subunit I | 3.6.3.14 | cgd4_1470 |
Vacuolar ATP synthase subunit C | 3.6.3.14 | cgd4_540 |
Vacuolar ATP synthase AC39 subunit | 3.6.3.14 | cgd5_3340 |
Vacuolar ATP synthase subunit D | 3.6.3.14 | cgd5_530 |
Vacuolar ATP synthase subunit F | 3.6.3.14 | cgd5_850 |
Vacuolar ATP synthase catalytic subunit A | 3.6.3.14 | cgd7_5000 |
Vacuolar ATP synthase subunit B | 3.6.3.14 | cgd8_1670 |
Vacuolar ATP synthase subunit E | 3.6.3.14 | cgd8_360 |
Vacuolar ATP synthase 22kDa proteolipid subunit | 3.6.3.14 | cgd8_4790 |
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