Proline metabolism

Proline is a non essential amino acid which is de novo synthesised from glutamate (glutamate metabolism pathway) in Cryptosporidium species [1]. This pathway shows the enzymes which catalyse the conversion of proline into 4-hydroxy-L-proline and pyrroline-5-carboxylate. The enzyme ornithine aminotransferase present in Toxoplasma gondii is absent in Cryptosporidium species. In addition, arginase (converts arginine into ornithine) present in Plasmodium falciparum is absent in Coccidia including Cryptosporidia and has led to the shortening of arginine and proline metabolism pathway in MPMP to proline metabolism pathway here.


Enzyme EC Number Gene id
Proline hydroxylase cgd3_3910
Pyrroline-5-carboxylate reductase cgd6_3720
Pro-tRNA ligase cgd6_4400


List of genes annotated as tRNA-Pro in C. parvum genome


cgd4_1555 cgd4_1556 cgd6_3715


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Sources and fates of metabolites


Substrate Source pathways Product Fate pathways
Proline Glutamate metabolism 4-hydroxy-L-proline ?
2-oxoglutarate Host Succinate Host