Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].


Enzyme EC Number Gene id
Serine hydroxymethyltransferase cgd8_2580
Serine hydroxymethyltransferase cgd8_2610
Serine-tRNA ligase cgd8_4720
Glycine-tRNA ligase cgd8_1030



List of genes annotated as tRNA-Gly in C. parvum genome


cgd1_3095 cgd3_3315 cgd7_4025


List of genes annotated as tRNA-Ser in C. parvum genome


cgd6_2495 cgd6_4925 cgd7_2035


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Sources and fates of metabolic pathways


Substrate Source pathways Product Fate pathways
Serine Host    
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate