Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].

 

Enzyme EC Number Gene id
Serine hydroxymethyltransferase 2.1.2.1 CMU_026590
Serine hydroxymethyltransferase 2.1.2.1 CMU_026630
Serine-tRNA ligase 6.1.1.11 CMU_042090
Glycine-tRNA ligase 6.1.1.14 CMU_024930

 

List of genes annotated as tRNA-Gly in C. muris genome

 

CMU_000200 CMU_014150 CMU_029890

 

List of genes annotated as tRNA-Ser in C. muris genome

 

CMU_007350 CMU_011180 CMU_034070

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Serine Host    
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate