Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].


Enzyme EC Number Gene id
Serine hydroxymethyltransferase Chro.80302
Serine hydroxymethyltransferase Chro.80306
Serine-tRNA ligase Chro.80542
Glycine-tRNA ligase Chro.80123



List of genes annotated as tRNA-Gly in C. hominis genome


Chro.trn006 Chro.trn033 Chro.trn043


List of genes annotated as tRNA-Ser in C. hominis genome


Chro.trn009 Chro.trn016 Chro.trn037


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Sources and fates of metabolic pathways


Substrate Source pathways Product Fate pathways
Serine Host    
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate