Nitrogen metabolism
Nitrogen metabolism pathway is a metabolic capability which is same in Toxoplasma gondii and Plasmodium falciparum. This shows the utilisation of nitrate and nitrite from host as source of nitrogen and the de novo synthesis of non essential amino acids glutamate and glutamine from it. The nitrogen metabolism pathway of Piroplasma species possess the capability to utilise nitrites and nitrates to produce glutamate and carbamoyl phosphate. The de novo synthesis of glutamine is absent in these species
Enzyme | EC Number | Gene id |
---|---|---|
Glutamate dehydrogenase (NAD-specific) | 1.4.1.2 | BBOV_III009680 |
Glutamate dehydrogenase (NADP-specific) | 1.4.1.4 | BBOV_IV010390 |
Nitrate reductase | 1.7.1.3 | BBOV_II005800 |
Nitrite reductase | 1.7.1.4 | BBOV_III001680 |
Carbamoyl-phosphate synthase | 6.3.4.16 | BBOV_III003590 |
Nitrite transporter | none | BBOV_I000410 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Nitrate | Host | Carbamoylphosphate | Pyrimidine metabolism |
Nitrite | Host | L-Glutamate | Glutamate metabolism |
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