Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Piroplasma genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase subunit C 3.6.3.14 TP02_0034
Vacuolar ATP synthase subunit F 3.6.3.14 TP02_0445
Vacuolar ATP synthase subunit D 3.6.3.14 TP02_0488
Vacuolar ATP synthase 54 kDa proteolipid subunit 3.6.3.14 TP03_0033
Vacuolar ATP synthase subunit G1 3.6.3.14 TP03_0686
Vacuolar ATP synthase subunit E 3.6.3.14 TP03_0853
Vacuolar ATP synthase 16 kDa proteolipid subunit 3.6.3.14 TP04_0317
Vacuoloar ATP synthase AC39 subunit 3.6.3.14 TP04_0436
Vacuolar ATP synthase subunit B 3.6.3.14 TP04_0441
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 TP04_0714
Vacuolar ATP synthase subunit I 3.6.3.14 TP04_0731
Vacuolar ATP synthase 22 kDa proteolipid subunit 3.6.3.14 TP04_0832