Nitrogen metabolism

Nitrogen metabolism pathway is a metabolic capability which is same in Toxoplasma gondii and Plasmodium falciparum. This shows the utilisation of nitrate and nitrite from host as source of nitrogen and the de novo synthesis of non essential amino acids glutamate and glutamine from it. The nitrogen metabolism pathway of Piroplasma species possess the capability to utilise nitrites and nitrates to produce glutamate and carbamoyl phosphate. The de novo synthesis of glutamine is absent in these species

 

Enzyme EC Number Gene id
Glutamate dehydrogenase (NAD-specific) 1.4.1.2 TP04_0883
Glutamate dehydrogenase (NADP-specific) 1.4.1.4 Missing in annotation (Absent)
Nitrate reductase 1.7.1.3 TP02_0545
Nitrite reductase 1.7.1.4 TP03_0672
Carbamoyl-phosphate synthase 6.3.4.16 TP03_0048
Nitrite transporter none TP02_0918

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Nitrate Host Carbamoylphosphate Pyrimidine metabolism
Nitrite Host L-Glutamate Glutamate metabolism