Methionine metabolism
Methionine, an essential amino acid in humans is also essential to all apicomplexans and need to be salvaged from the host. The methionine metabolism pathway in Piroplasma is essential for providing S-adenosylmethionine, the methyl group donor in various reactions. A metabolic capability which is present in Plasmodium falciparum and absent in Coccidia and Piroplasma is the synthesis of polyamines such as spermine and spermidine. This has been incorporated with methionine metabolism in MPMP (methionine and polyamine metabolism). The genes coding for the enzymes ornithine decarboxylase, arginine decarboxylase and spermine/spermidine synthase are absent in the genomes of Piroplasma. The back conversion of putrescine from spermine present in Coccidia is also absent in Piroplasma.
Enzyme | EC Number | Gene id |
---|---|---|
S-adenosyl-methyltransferase | 2.1.1.- | TP01_0113 |
S-adenosyl-methyltransferase | 2.1.1.- | TP03_0020 |
Homocysteine S-methyltransferase | 2.1.1.10 | Missing in annotation |
Methionine adenosyl transferase | 2.5.1.6 | TP04_0893 |
Adenosylhomocysteinase | 3.3.1.1 | TP03_0160 |
Met-tRNA ligase | 6.1.1.10 | TP01_1212 |
Met-tRNA ligase | 6.1.1.10 | TP03_0137 |
tRNA binding protein | none | TP02_0124 |
List of genes annotated as tRNA-Met in T. parva genome
TP02_0976 | TP04_0934 | TP05_0051 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Methionine | Host | Adenosine | Purine metabolism |
Examples of adenosylmethionine-dependent methyltransferases in Theileria parva genome
Enzyme | EC Number | Gene id |
---|---|---|
DNA (cytosine-5-)-methyltransferase | 2.1.1.37 | TP04_0566 |
mRNA(2'-D-methyladenosine-N6)-methyltransferase | 2.1.1.62 | TP01_0343 |
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