Mannose and fructose metabolism

The mannose and fructose metabolism pathway presented here is shorter than the pathway for Toxoplasma gondii. This pathway utilises fructose, a hexose (may be from host) and fructose-6-phosphate, a glycolysis intermediate for the production of important nucleotide sugar GDP-D-mannose in Theileria species. This is an essential substrate for glycosylphosphatidylinositol (GPI) anchor biosynthesis and dolichol metabolism. GDP-L-fucose is also synthesised in T. gondii and Plasmodium falciparum, which is missing in Cryptosporidium and Theileria species.

 

Enzyme EC Number Gene id
Hexokinase 2.7.1.1 TP01_0043
Hexokinase 2.7.1.1 TP01_0045
Mannose-1-phosphate guanylyltransferase 2.7.7.13 TP02_0639
Mannose-6-phosphate isomerase 5.3.1.8 TP04_0879
Phosphomannomutase 5.4.2.8 TP01_0785

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
beta-D-Fructose-6P Glycolysis GDP-D-Mannose Dolichol metabolism
beta-D-Fructose Host    
D-Mannose Host