Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possess the ability to synthesise glycine, serine and cysteine, whereas Plasmodium, Cryptosporidium and Piroplasma can only synthesise glycine de novo and salvage serine and cysteine from hosts [1]. Piroplasma possess the glycine cleavage system present in Toxoplasma, Neospora and Plasmodium species and absent in Cryptosporidium species.

 

Enzyme EC Number Gene id
Glycine dehydrogenase 1.4.4.2 Missing in annotation
Dihydrolipoyl dehydrogenase 1.8.1.4 TP03_0227
Serine hydroxymethyltransferase 2.1.2.1 TP01_0390
Aminomethyltransferase 2.1.2.10 TP01_0480
Aminomethyltransferase 2.1.2.10 TP01_0521
Serine-tRNA ligase 6.1.1.11 TP01_0161
Glycine-tRNA ligase 6.1.1.14 TP01_0460

 

List of genes annotated as tRNA-Gly in T. parva genome

 

TP01_1246 TP04_0933 TP04_0941
TP05_0049    

 

List of genes annotated as tRNA-Ser in T. parva genome

 

TP03_0941 TP03_0942 TP04_0932
TP04_0935 TP05_0057 TP05_0062

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate