Dolichol metabolism

Dolichol metabolism pathway shows the synthesis of dolichyl D-mannosyl phosphate, a substrate of GPI anchor biosynthesis pathway from dolichol acquired from host. The dolichol metabolism pathway is also present in Plasmodium falciparum. Plasmodium can synthesise dolichyl phosphate from both dolichol and dolichyl diphosphate, whereas Piroplasma can only phosphorylate dolichol to dolichyl phosphate. Dolichyl D-mannosyl phosphate is also a substrate for N-glycans. The enzymes for N-glycan synthesis is absent in both Plasmodium and Piroplasma species. The N-glycan biosynthesis is present in the Coccidia branch of Apicomplexa.

 

Enzyme EC Number Gene id
Dolichyl-phosphate beta-D-mannosyltransferase (DPM1) 2.4.1.83 TP02_0741
Dolichol kinase 2.7.1.108 TP02_0702
Nucleoside diphosphate kinase 2.7.4.6 TP02_0422

 

Open in a new window

 

 

Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Dolichol Host Dolichylphosphate D-mannose GPI anchor biosynthesis
GDP-mannose Mannose and fructose metabolism