Aminosugars metabolism

The metabolic pathway of aminosugars metabolism in Piroplasma species is same as the pathway in Toxoplasma gondii. Theileria parva possesses gene orthologs for all the enzymes present in T. gondii except 2.4.1.119. The enzyme 2.3.1.4 missing in Plasmodium falciparum and T. gondii is also missing in all Piroplasma species. This pathway is important for the post-translational modification, N-linked glycosylation of proteins. N-linked glycosylation is the attachment of oligosaccharide chains to Asn in the tripeptide sequence Asn-X-Ser/Thr (X - any amino acid except Pro) of proteins and this facilitates the correct folding of some proteins.

 

Enzyme EC Number Gene id
Glucosamine-phosphate N-acetyltransferase 2.3.1.4 Missing in annotation
Dolichyl-diphosphooligosaccharide-protein glycotransferase 2.4.1.119 Missing in annotation
UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase 2.4.1.141 TP02_0515
Glutamine-fructose-6-phosphate transaminase 2.6.1.16 TP02_0935
UDP-N-acetylglucosamine diphosphorylase 2.7.7.23 TP01_0489
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephospho transferase 2.7.8.15 TP01_0118
Phosphoacetylglucosamine mutase 5.4.2.3 TP02_0925

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
D-Fructose-6P Glycolysis    
L-glutamine Host L-glutamate Glutamate metabolism
UTP Pyrimidine metabolism    
Dolichyl phosphate Dolichol metabolism Dolichyl pyrophosphate ?