Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Piroplasma genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase 54 kDa proteolipid subunit 3.6.3.14 TA02610
Vacuolar ATP synthase subunit E 3.6.3.14 TA03545
Vacuolar ATP synthase 16 kDa proteolipid subunit 3.6.3.14 TA07825
Vacuoloar ATP synthase AC39 subunit 3.6.3.14 TA08420
Vacuolar ATP synthase subunit B 3.6.3.14 TA08450
Vacuolar ATP synthase subunit I 3.6.3.14 TA10280
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 TA10370
Vacuolar ATP synthase 22 kDa proteolipid subunit 3.6.3.14 TA11325
Vacuolar ATP synthase subunit C 3.6.3.14 TA12310
Vacuolar ATP synthase subunit F 3.6.3.14 TA13210
Vacuolar ATP synthase subunit D 3.6.3.14 TA13470
Vacuolar ATP synthase subunit E 3.6.3.14 TA17420
Vacuolar ATP synthase subunit G1 3.6.3.14 TA17730