Terpenoid metabolism

Terpenoids are produced from the 5-carbon isoprene units, isopentenyl diphosphate and dimethylallyl diphosphate. The pathway which produces the 5-carbon isoprene units is absent is Cryptosporidium species and need to be acquired from host. Terpenoids are used as precursors for production of sterols and steroids in animals. Some proteins have terpenoid moieties attached to them in order to enhance their attachment to membranes. This pathway produces polyprenyl pyrophosphate, undecaprenyl pyrophosphate and prenylated proteins such as S-geranylgeranyl protein as the end products of the pathway. This pathway is identical to the pathways of Plasmodium falciparum and Toxoplasma gondii.

 

Enzyme EC Number Gene id
Methyltransferase, MiaB 2.1.1.- TA11010
Farnesylpyrophosphate synthase (Dimethylallyl-PP transferase/Geranyl transferase) 2.5.1.1; 2.5.1.10 TA17400
Protein farnesyltransferase 2.5.1.29; 2.5.1.58 TA15255
trans-pentaprenyltranstransferase/trans-hexaprenyltranstransferase/trans-octaprenyltranstransferase 2.5.1.30; 2.5.1.82; 2.5.1.84 TA03505
di-trans,poly-cis-decaprenylcistransferase 2.5.1.31 TA04455
Protein geranylgeranyltransferase type I 2.5.1.59 TA04900
Protein geranylgeranyltransferase type II 2.5.1.60 TA11140
tRNA isopentenyltransferase 2.5.1.75 TA20750
Inorganic diphosphatase 3.6.1.1 TA13735

 

Open in a new window

 

 

Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
S-adenosylmethionine Methionine metabolism S-adenosylhomocysteine Methionine metabolism
Dimethylallyl-PP Isoprenoids metabolism    
Isopentenyl-PP Isoprenoids metabolism