Nitrogen metabolism

Nitrogen metabolism pathway is a metabolic capability which is same in Toxoplasma gondii and Plasmodium falciparum. This shows the utilisation of nitrate and nitrite from host as source of nitrogen and the de novo synthesis of non essential amino acids glutamate and glutamine from it. The nitrogen metabolism pathway of Piroplasma species possess the capability to utilise nitrites and nitrates to produce glutamate and carbamoyl phosphate. The de novo synthesis of glutamine is absent in these species

 

Enzyme EC Number Gene id
Glutamate dehydrogenase (NAD-specific) 1.4.1.2 TA11105
Glutamate dehydrogenase (NADP-specific) 1.4.1.4 Missing in annotation (Absent)
Nitrate reductase 1.7.1.3 TA13765
Nitrite reductase 1.7.1.4 TA17660
Carbamoyl-phosphate synthase 6.3.4.16 TA02545
Nitrite transporter none TA15830

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Nitrate Host Carbamoylphosphate Pyrimidine metabolism
Nitrite Host L-Glutamate Glutamate metabolism