Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possess the ability to synthesise glycine, serine and cysteine, whereas Plasmodium, Cryptosporidium and Piroplasma can only synthesise glycine de novo and salvage serine and cysteine from hosts [1]. Piroplasma possess the glycine cleavage system present in Toxoplasma, Neospora and Plasmodium species and absent in Cryptosporidium species.

 

Enzyme EC Number Gene id
Glycine dehydrogenase 1.4.4.2 Missing in annotation
Dihydrolipoyl dehydrogenase 1.8.1.4 TA03445
Serine hydroxymethyltransferase 2.1.2.1 TA20940
Aminomethyltransferase 2.1.2.10 TA20635
Serine-tRNA ligase 6.1.1.11 TA03465
Serine-tRNA ligase 6.1.1.11 TA19195
Glycine-tRNA ligase 6.1.1.14 TA20715

 

List of genes annotated as tRNA-Gly in T. annulata genome

 

TA06963 TA08123 TA10018

 

List of genes annotated as tRNA-Ser in T. annulata genome

 

TA03603 TA03604 TA08333
TA08473    

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate