Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, only the S1 subunit of V0 domain is missing in Toxoplasma gondii and Neospora caninum genomes.

 

Protein EC Number Gene id
Vacuolar ATP synthase 54 kDa proteolipid subunit 3.6.3.14 NCLIV_003220
Vacuolar ATP synthase subunit D 3.6.3.14 NCLIV_023610
Vacuolar ATP synthase AC39 subunit 3.6.3.14 NCLIV_027480
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 NCLIV_029990
Vacuolar ATP synthase subunit I 3.6.3.14 NCLIV_032770
Vacuolar ATP synthase subunit I 3.6.3.14 NCLIV_042690
Vacuolar ATP synthase 22 kDa proteolipid subunit 3.6.3.14 NCLIV_043040
Vacuolar ATP synthase subunit E 3.6.3.14 NCLIV_043880
Vacuolar ATP synthase 16 kDa proteolipid subunit 3.6.3.14 NCLIV_049080
Vacuolar ATP synthase subunit F 3.6.3.14 NCLIV_054960
Vacuolar ATP synthase subunit C 3.6.3.14 NCLIV_058310
Vacuolar ATP synthase subunit B 3.6.3.14 NCLIV_060820
Vacuolar ATP synthase subunit G1 3.6.3.14 NCLIV_063350
Vacuolar ATP synthase subunit H 3.6.3.14 NCLIV_066570
Vacuolar type H+-ATPase proteolipid subunit 3.6.3.14 Missing in annotation