Lysine degradation

Toxoplasma gondii and Neospora caninum have saccharopine dehydrogenase which catalyse the degradation of lysine. This pathway also includes large number of genes coding histone-lysine N-methyltransferase which catalyses protein methylation and acylaminoacyl-peptidase, which hydrolyses trimethyl-lysine from protein.

 

Enzyme EC Number Gene id
Saccharopine dehydrogenase 1.5.1.7 NCLIV_052240
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_001510
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_002210
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_011360
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_025110
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_028480
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_029100
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_040830
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_043370
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_046190
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_055430
Histone-lysine N-methyltransferase 2.1.1.43 NCLIV_060040
Acylaminoacyl-peptidase 3.4.19.1 NCLIV_063570
Lysine-tRNA ligase 6.1.1.6 NCLIV_012460
Lysine-tRNA ligase 6.1.1.6 NCLIV_019960

 

List of genes annotated as tRNA-Lys in N. caninum genome

 

NC_LIV_tRNA_070001 NC_LIV_tRNA_070002 NC_LIV_tRNA_070003 NC_LIV_tRNA_100016
NC_LIV_tRNA_100017 NC_LIV_tRNA_100018 NC_LIV_tRNA_120004 NC_LIV_tRNA_130013
NC_LIV_tRNA_130015 NC_LIV_tRNA_140007    

 

Open in a new window

 

 

Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Lysine Lysine biosynthesis Saccharopine Host?