Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Cryptosporidium genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 cgd1_520
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 cgd1_540
Vacuolar ATP synthase subunit G1 3.6.3.14 cgd2_250
Vacuolar ATP synthase 54kDa proteolipid subunit 3.6.3.14 cgd2_3960
Vacuolar ATP synthase subunit I 3.6.3.14 cgd4_1470
Vacuolar ATP synthase subunit C 3.6.3.14 cgd4_540
Vacuolar ATP synthase AC39 subunit 3.6.3.14 cgd5_3340
Vacuolar ATP synthase subunit D 3.6.3.14 cgd5_530
Vacuolar ATP synthase subunit F 3.6.3.14 cgd5_850
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 cgd7_5000
Vacuolar ATP synthase subunit B 3.6.3.14 cgd8_1670
Vacuolar ATP synthase subunit E 3.6.3.14 cgd8_360
Vacuolar ATP synthase 22kDa proteolipid subunit 3.6.3.14 cgd8_4790