Glycine and serine metabolism
Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].
Enzyme | EC Number | Gene id |
---|---|---|
Serine hydroxymethyltransferase | 2.1.2.1 | cgd8_2580 |
Serine hydroxymethyltransferase | 2.1.2.1 | cgd8_2610 |
Serine-tRNA ligase | 6.1.1.11 | cgd8_4720 |
Glycine-tRNA ligase | 6.1.1.14 | cgd8_1030 |
List of genes annotated as tRNA-Gly in C. parvum genome
cgd1_3095 | cgd3_3315 | cgd7_4025 |
List of genes annotated as tRNA-Ser in C. parvum genome
cgd6_2495 | cgd6_4925 | cgd7_2035 |
cgd8_4745 |
Sources and fates of metabolic pathways
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Serine | Host | ||
Tetrahydrofolate | Recycling of folate | 5,10-methylene tetrahydrofolate | Recycling of folate |
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