Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].

 

Enzyme EC Number Gene id
Serine hydroxymethyltransferase 2.1.2.1 cgd8_2580
Serine hydroxymethyltransferase 2.1.2.1 cgd8_2610
Serine-tRNA ligase 6.1.1.11 cgd8_4720
Glycine-tRNA ligase 6.1.1.14 cgd8_1030

 

 

List of genes annotated as tRNA-Gly in C. parvum genome

 

cgd1_3095 cgd3_3315 cgd7_4025

 

List of genes annotated as tRNA-Ser in C. parvum genome

 

cgd6_2495 cgd6_4925 cgd7_2035
cgd8_4745    

 

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Sources and fates of metabolic pathways

 

Substrate Source pathways Product Fate pathways
Serine Host    
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate