Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Cryptosporidium genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase 54kDa proteolipid subunit 3.6.3.14 CMU_003000
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 CMU_005350
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 CMU_005370
Vacuolar ATP synthase subunit G1 3.6.3.14 CMU_010180
Vacuolar ATP synthase 22kDa proteolipid subunit 3.6.3.14 CMU_011240
Vacuolar ATP synthase subunit C 3.6.3.14 CMU_012660
Vacuolar ATP synthase AC39 subunit 3.6.3.14 CMU_015820
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 CMU_019130
Vacuolar ATP synthase subunit E 3.6.3.14 CMU_024280
Vacuolar ATP synthase subunit B 3.6.3.14 CMU_025620
Vacuolar ATP synthase subunit I 3.6.3.14 CMU_028580
Vacuolar ATP synthase subunit F 3.6.3.14 CMU_041040
Vacuolar ATP synthase subunit D 3.6.3.14 CMU_041380