Terpenoid metabolism

Terpenoids are produced from the 5-carbon isoprene units, isopentenyl diphosphate and dimethylallyl diphosphate. The pathway which produces the 5-carbon isoprene units is absent is Cryptosporidium species and need to be acquired from host. Terpenoids are used as precursors for production of sterols and steroids in animals. Some proteins have terpenoid moieties attached to them in order to enhance their attachment to membranes. This pathway produces polyprenyl pyrophosphate, undecaprenyl pyrophosphate and prenylated proteins such as S-geranylgeranyl protein as the end products of the pathway. This pathway is identical to the pathways of Plasmodium falciparum and Toxoplasma gondii.

 

Enzyme EC Number Gene id
Methyltransferase, MiaB 2.1.1.- CMU_008420
Farnesylpyrophosphate synthase (Dimethylallyl-PP transferase/Geranyl transferase) 2.5.1.1; 2.5.1.10 CMU_017570
Protein farnesyltransferase 2.5.1.29; 2.5.1.58 CMU_028740
trans-pentaprenyltranstransferase/trans-hexaprenyltranstransferase/trans-octaprenyltranstransferase 2.5.1.30; 2.5.1.82; 2.5.1.84 CMU_013790
di-trans,poly-cis-decaprenylcistransferase 2.5.1.31 CMU_028620
Protein geranylgeranyltransferase type I 2.5.1.59 CMU_008140
Protein geranylgeranyltransferase type II 2.5.1.60 CMU_019450
tRNA isopentenyltransferase 2.5.1.75 CMU_007290
Inorganic diphosphatase 3.6.1.1 CMU_028510

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
S-adenosylmethionine Methionine metabolism S-adenosylhomocysteine Methionine metabolism
Dimethylallyl-PP Host Farnesyl-PP N-glycan biosynthesis
Isopentenyl-PP Host