Proline is a non essential amino acid which is de novo synthesised from glutamate (glutamate metabolism pathway) in Cryptosporidium species . This pathway shows the enzymes which catalyse the conversion of proline into 4-hydroxy-L-proline and pyrroline-5-carboxylate. The enzyme ornithine aminotransferase present in Toxoplasma gondii is absent in Cryptosporidium species. In addition, arginase (converts arginine into ornithine) present in Plasmodium falciparum is absent in Coccidia including Cryptosporidia and has led to the shortening of arginine and proline metabolism pathway in MPMP to proline metabolism pathway here.
|Enzyme||EC Number||Gene id|
List of genes annotated as tRNA-Pro in C. muris genome
Sources and fates of metabolites
|Substrate||Source pathways||Product||Fate pathways|
|2-oxoglutarate||Tricarboxylic acid (TCA) cycle||Succinate||Tricarboxylic acid (TCA) cycle|