Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Cryptosporidium genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 Chro.10062
Vacuolar ATP synthase 16kDa proteolipid subunit 3.6.3.14 Chro.10063
Vacuolar ATP synthase subunit G1 3.6.3.14 Chro.20032
Vacuolar ATP synthase 54kDa proteolipid subunit 3.6.3.14 Chro.20424
Vacuolar ATP synthase subunit C 3.6.3.14 Chro.40070
Vacuolar ATP synthase subunit I 3.6.3.14 Chro.40167
Vacuolar ATP synthase AC39 subunit 3.6.3.14 Chro.50039
Vacuolar ATP synthase subunit F 3.6.3.14 Chro.50302
Vacuolar ATP synthase subunit D 3.6.3.14 Chro.50340
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 Chro.70559
Vacuolar ATP synthase subunit E 3.6.3.14 Chro.80048
Vacuolar ATP synthase subunit B 3.6.3.14 Chro.80195
Vacuolar ATP synthase 22kDa proteolipid subunit 3.6.3.14 Chro.80551