Terpenoid metabolism

Terpenoids are produced from the 5-carbon isoprene units, isopentenyl diphosphate and dimethylallyl diphosphate. The pathway which produces the 5-carbon isoprene units is absent is Cryptosporidium species and need to be acquired from host. Terpenoids are used as precursors for production of sterols and steroids in animals. Some proteins have terpenoid moieties attached to them in order to enhance their attachment to membranes. This pathway produces polyprenyl pyrophosphate, undecaprenyl pyrophosphate and prenylated proteins such as S-geranylgeranyl protein as the end products of the pathway. This pathway is identical to the pathways of Plasmodium falciparum and Toxoplasma gondii.

 

Enzyme EC Number Gene id
Methyltransferase, MiaB 2.1.1.- Chro.60189
Farnesylpyrophosphate synthase (Dimethylallyl-PP transferase/Geranyl transferase) 2.5.1.1; 2.5.1.10 Chro.40285
Protein farnesyltransferase 2.5.1.29; 2.5.1.58 Chro.10227
trans-pentaprenyltranstransferase/trans-hexaprenyltranstransferase/trans-octaprenyltranstransferase 2.5.1.30; 2.5.1.82; 2.5.1.84 Chro.70416
di-trans,poly-cis-decaprenylcistransferase 2.5.1.31 Missing in annotation
Protein geranylgeranyltransferase type I 2.5.1.59 Chro.60212
Protein geranylgeranyltransferase type II 2.5.1.60 Chro.70590
tRNA isopentenyltransferase 2.5.1.75 Chro.60293
Inorganic diphosphatase 3.6.1.1 Chro.40159

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
S-adenosylmethionine Methionine metabolism S-adenosylhomocysteine Methionine metabolism
Dimethylallyl-PP Host Farnesyl-PP N-glycan biosynthesis
Isopentenyl-PP Host