Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possesses the ability to synthesise glycine, serine and cysteine, whereas Cryptosporidia and Plasmodia can only synthesise glycine de novo and salvage serine and cysteine from hosts [1].

 

Enzyme EC Number Gene id
Serine hydroxymethyltransferase 2.1.2.1 Chro.80302
Serine hydroxymethyltransferase 2.1.2.1 Chro.80306
Serine-tRNA ligase 6.1.1.11 Chro.80542
Glycine-tRNA ligase 6.1.1.14 Chro.80123

 

 

List of genes annotated as tRNA-Gly in C. hominis genome

 

Chro.trn006 Chro.trn033 Chro.trn043

 

List of genes annotated as tRNA-Ser in C. hominis genome

 

Chro.trn009 Chro.trn016 Chro.trn037
Chro.trn042    

 

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Sources and fates of metabolic pathways

 

Substrate Source pathways Product Fate pathways
Serine Host    
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate