Vacuolar-ATPase

Vacuolar-H+-ATPase is an enzyme complex found in organelles such as lysosomes and endosomes and in plasma membranes of eukaryotes. These V-ATPases couple the energy generated from ATP hydrolysis to pump protons across the membranes. They can serve many functions such as Ca2+ uptake, pH homeostasis and coupled transport. They have two domains V0 and V1 like the mitochondrial ATP synthase complexes (F0 and F1 domains). The V0 domain has five subunits and V1 has eight subunits. Of these, the S1 subunit of V0 domain is missing in all apicomplexans. The subunit H of V1 domain present in Toxoplasma gondii is missing in Piroplasma genomes.

 

Enzyme EC Number Gene id
Vacuolar ATP synthase subunit E 3.6.3.14 BBOV_I000090
Vacuolar ATP synthase subunit B 3.6.3.14 BBOV_II001490
Vacuoloar ATP synthase AC39 subunit 3.6.3.14 BBOV_II001540
Vacuolar ATP synthase 16 kDa proteolipid subunit 3.6.3.14 BBOV_II002740
Vacuolar ATP synthase subunit G1 3.6.3.14 BBOV_III001560
Vacuolar ATP synthase 54 kDa proteolipid subunit 3.6.3.14 BBOV_III004100
Vacuolar ATP synthase subunit D 3.6.3.14 BBOV_III004650
Vacuolar ATP synthase subunit F 3.6.3.14 BBOV_III005090
Vacuolar ATP synthase catalytic subunit A 3.6.3.14 BBOV_III008150
Vacuolar ATP synthase subunit I 3.6.3.14 BBOV_III008300
Vacuolar ATP synthase 22 kDa proteolipid subunit 3.6.3.14 BBOV_III009220
Vacuolar ATP synthase subunit C 3.6.3.14 BBOV_III011050