Terpenoid metabolism

Terpenoids are produced from the 5-carbon isoprene units, isopentenyl diphosphate and dimethylallyl diphosphate. The pathway which produces the 5-carbon isoprene units is absent is Cryptosporidium species and need to be acquired from host. Terpenoids are used as precursors for production of sterols and steroids in animals. Some proteins have terpenoid moieties attached to them in order to enhance their attachment to membranes. This pathway produces polyprenyl pyrophosphate, undecaprenyl pyrophosphate and prenylated proteins such as S-geranylgeranyl protein as the end products of the pathway. This pathway is identical to the pathways of Plasmodium falciparum and Toxoplasma gondii.

 

Enzyme EC Number Gene id
Methyltransferase, MiaB 2.1.1.- Missing in annotation (Absent)
Farnesylpyrophosphate synthase (Dimethylallyl-PP transferase/Geranyl transferase) 2.5.1.1; 2.5.1.10 BBOV_I000120
Protein farnesyltransferase 2.5.1.29; 2.5.1.58 BBOV_III004550
trans-pentaprenyltranstransferase/trans-hexaprenyltranstransferase/trans-octaprenyltranstransferase 2.5.1.30; 2.5.1.82; 2.5.1.84 BBOV_IV007310
di-trans,poly-cis-decaprenylcistransferase 2.5.1.31 BBOV_IV002310
Protein geranylgeranyltransferase type I 2.5.1.59 BBOV_I004600
Protein geranylgeranyltransferase type II 2.5.1.60 BBOV_III009610
tRNA isopentenyltransferase 2.5.1.75 BBOV_IV006320
tRNA isopentenyltransferase 2.5.1.75 BBOV_IV006330
Inorganic diphosphatase 3.6.1.1 BBOV_III010840

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
S-adenosylmethionine Methionine metabolism S-adenosylhomocysteine Methionine metabolism
Dimethylallyl-PP Isoprenoids metabolism    
Isopentenyl-PP Isoprenoids metabolism