Glycine and serine metabolism

Coccidians such as Toxoplasma gondii and Neospora caninum possess the ability to synthesise glycine, serine and cysteine, whereas Plasmodium, Cryptosporidium and Piroplasma can only synthesise glycine de novo and salvage serine and cysteine from hosts [1]. Piroplasma possess the glycine cleavage system present in Toxoplasma, Neospora and Plasmodium species and absent in Cryptosporidium species.

 

Enzyme EC Number Gene id
Glycine dehydrogenase 1.4.4.2 Missing in annotation
Dihydrolipoyl dehydrogenase 1.8.1.4 BBOV_IV007190
Serine hydroxymethyltransferase 2.1.2.1 BBOV_IV005840
Aminomethyltransferase 2.1.2.10 BBOV_I001650
Aminomethyltransferase 2.1.2.10 BBOV_I003630
Serine-tRNA ligase 6.1.1.11 BBOV_IV001340
Serine-tRNA ligase 6.1.1.11 BBOV_IV007240
Glycine-tRNA ligase 6.1.1.14 BBOV_I003770

 

List of genes annotated as tRNA-Gly in B. bovis genome

 

BBOV_II002490 BBOV_III008790 BBOV_IV011060
BBOV_V000530    

 

List of genes annotated as tRNA-Ser in B. bovis genome

 

BBOV_II001450 BBOV_III002810 BBOV_IV007540
BBOV_IV007550 BBOV_V000250 BBOV_V000500

 

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Sources and fates of metabolites

 

Substrate Source pathways Product Fate pathways
Tetrahydrofolate Recycling of folate 5,10-methylene tetrahydrofolate Recycling of folate