Glycine and serine metabolism
Coccidians such as Toxoplasma gondii and Neospora caninum possess the ability to synthesise glycine, serine and cysteine, whereas Plasmodium, Cryptosporidium and Piroplasma can only synthesise glycine de novo and salvage serine and cysteine from hosts [1]. Piroplasma possess the glycine cleavage system present in Toxoplasma, Neospora and Plasmodium species and absent in Cryptosporidium species.
Enzyme | EC Number | Gene id |
---|---|---|
Glycine dehydrogenase | 1.4.4.2 | Missing in annotation |
Dihydrolipoyl dehydrogenase | 1.8.1.4 | BBOV_IV007190 |
Serine hydroxymethyltransferase | 2.1.2.1 | BBOV_IV005840 |
Aminomethyltransferase | 2.1.2.10 | BBOV_I001650 |
Aminomethyltransferase | 2.1.2.10 | BBOV_I003630 |
Serine-tRNA ligase | 6.1.1.11 | BBOV_IV001340 |
Serine-tRNA ligase | 6.1.1.11 | BBOV_IV007240 |
Glycine-tRNA ligase | 6.1.1.14 | BBOV_I003770 |
List of genes annotated as tRNA-Gly in B. bovis genome
BBOV_II002490 | BBOV_III008790 | BBOV_IV011060 |
BBOV_V000530 |
List of genes annotated as tRNA-Ser in B. bovis genome
BBOV_II001450 | BBOV_III002810 | BBOV_IV007540 |
BBOV_IV007550 | BBOV_V000250 | BBOV_V000500 |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
Tetrahydrofolate | Recycling of folate | 5,10-methylene tetrahydrofolate | Recycling of folate |
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