Aminosugars metabolism
The metabolic pathway of aminosugars metabolism in Toxoplasma gondii is same as the pathway in MPMP (http://sites.huji.ac.il/malaria/maps/aminosugmetpath.html) as T. gondii possesses gene orthologs for all the enzymes present in Plasmodium falciparum. The enzyme 2.3.1.4 missing in P. falciparum is also missing in Coccidians, T. gondii and Neospora caninum. This pathway is important for the post-translational modification, N-linked glycosylation of proteins. N-linked glycosylation is the attachment of oligosaccharide chains to Asn in the tripeptide sequence Asn-X-Ser/Thr (X - any amino acid except Pro) of proteins and this facilitates the correct folding of some proteins.
Enzyme | EC Number | Gene id | Protein localisation | Localisation data source |
---|---|---|---|---|
Glucosamine-phosphate N-acetyltransferase | 2.3.1.4 | Missing in annotation | ||
Dolichyl-diphosphooligosaccharide -protein glycotransferase | 2.4.1.119 | TGME49_203970 | Endoplasmic reticulum membrane | Go annotation |
Dolichyl-diphosphooligosaccharide -protein glycotransferase | 2.4.1.119 | TGME49_231430 | Plasma membrane | Go annotation; Previous publication |
UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase | 2.4.1.141 | TGME49_268340 | ||
Glutamine-fructose-6-phosphate transaminase | 2.6.1.16 | TGME49_231350 | Apicoplast | Previous publication |
UDP-N-acetylglucosamine diphosphorylase | 2.7.7.23 | TGME49_264780 | ||
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephospho transferase | 2.7.8.15 | TGME49_244520 | Membrane | Go annotation |
Phosphoacetylglucosamine mutase | 5.4.2.3 | TGME49_264650 | Plasma membrane | Previous publication |
Sources and fates of metabolites
Substrate | Source pathways | Product | Fate pathways |
---|---|---|---|
D-Fructose-6P | Glycolysis | ||
L-glutamine | Glutamate metabolism | L-glutamate | Glutamate metabolism |
UTP | Pyrimidine metabolism | ||
Dolichyl phosphate | N-glycan biosynthesis | Dolichyl pyrophosphate | N-glycan biosynthesis |
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